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Common cold is almost always accompanied by cough. But, given that cough is not a disease but body reaction aimed at protecting and cleansing respiratory tract, it is necessary to assist it in carrying out its natural function, but nor suppressing it.

As a rule sticky mucus and spasms in bronchi strongly inhibit natural cleansing of respiratory tract. Prospan® herbal preparation can help to cope with cough by making sputum less thick and exerting best efforts to its active excretion and elimination of obstacles on its way i.e. spasms in bronchial tree.

Prospan®* is German herbal medication based on the original standardized dry extract of ivy leaves (used only for Prospan® production). Prospan® is designed to treat any type of cough, to include smoker’s cough, as it is strong herbal expectorant with pronounced and proven broncholytic action. Prospan® does not contain alcohol, dyes and sugar. As it has been already mentioned, Prospan® contributes to liquefaction of mucus, its active excretion from the respiratory tract and, most importantly, relieves muscle spasm in bronchial tubes. Prospan® advantages also include its usability in all age groups, starting from babies, and pleasant taste and a variety of dosage forms: syrup, effervescent tablets Forte and solution in sticks.

Are you coughing? – Take Prospan®!

Prospan syrup: produced by Engelhard Arzneimittel GmbH & Co. KG (Germany), Marketing Authorization No. UA/0672/02/01; Prospan Forte effervescent tablets: produced by Engelhard Arzneimittel GmbH & Co. KG (Germany), Marketing Authorization No. UA/0672/01/01.

5 ml Prospan solution: produced by Engelhard Arzneimittel GmbH & Co. KG  (Germany), Marketing Authorization No. UA/0672/03/01.

*Drug advertising. Read instructions carefully and consult a doctor before use. Keep out of the reach of children.

Self-medication can be harmful to your health

Engelhard Arzneimittel R05C A16

Coughing? Prospan!

Prospan® cough syrup
Syrup vial 100 mL, with a measuring cup, No. 1, in a cardboard box.

Dry extract from ivy leaves (5-7.5:1) 7 mg/mL

Additional substances: Potassium sorbate, anhydrous citric acid, xanthum gum, cherry flavoring agent, crystallizing sorbite solution, purified water.
2.5 mL of syrup contains 0.963 g of sugar surrogate, sorbitol, which is equivalent to 0.08 bread unit.

Extraction fluid: Ethanol 30% (by mass).

Prospan® forte, fizzy cough pills
fizzy pills  in a tube, 65 mg, No. 10, 1 tube in a cardboard box.

Dry extract from ivy leaves (5-7.5:1) 65 mg

Additional substances: Anhydrous citric acid, sodium hydrocarbonate, anhydrous sodium carbonate, mannitol, simethicone, sodium saccharin, sodium cyclamate, sodium citrate, sorbite, medium chain triglycerides, macrogol glycerol hydroxystearate, flavoring agent.  
1 fizzy pill contains 0.04 bread unit that shall be taken into consideration by patients with diabetes mellitus.

Prospan® cough solution
Oral solution, 35 mg/5 ml stick, No. 21, in a cardboard box.

Dry extract from ivy leaves (5-7.5:1) 35 mg/5 mL

Additional substances: Potassium sorbate, crystallizing sorbite solution, 70%, anhydrous citric acid, xanthum gum, menthol, purified water, natural orange flavoring agent, Fresko Fort Permaseal flavoring agent.
5 mL of the solution contains 1.9 g of sorbite, that is equivalent to 0.16 bread unit.

Extraction fluid: Ethanol 30% (by mass).

Pharmacotherapeutic group: Medications used for curing cough and catarrhal diseases. Expectorants. ATC code: R05C A16.

Acute and chronic inflammatory diseases of respiratory tract, with cough and formation of hard to separate secret; acute and chronic bronchitis, especially with obstruction syndrome; butylamine.

Counterindications: Intolerance to fructose, high sensitivity to any medication ingredient.

Adverse effects:
The medication is generally well tolerated; development of purgative effect is possible (after intaking syrup); individual intolerance to components; in rare cases, allergic reactions (itch, skin reddening, skin rash, urticaria, oedema, dyspnea) may occur; very rarely, in patients with high sensitivity, gactrointestinal disorders (nausea, vomiting, diarrhea) are possible.

Adverse interactions in case of simultaneous intaking Prospan pills and other medications so far have not been observed. That is why the medication may be used simultaneously with other medications – for example, with antibiotics.

In case of intaking the medication enlarge quantities (more then 3 times as large as the daily dosage) nausea, vomiting, and diarrhea are possible. The treatment is symptomatic.

Storage requirements: To be kept at up to 25°C, inaccessible for children.

Shelf life: 3 years.

Sell condition: over the counter.

The Prospan medication contains standardized dry extract of ivy leaves with pharmacologically proved and therapeutically confirmed therapeutic effect against respiratory tract inflammatory diseases that is based on secretolytic, mucolytic, mucokinetic, spasmolytic, and soft cough-depressant properties of glycosides (saponins) it contains. Secretolytic effect of the extract is based on properties of saponin glycosides contained in ivy leaves; the baseline of its spasmolytic properties are parasympatholytic effects of certain glycosides contained by the medication. Activation of β2 receptors in cells of bronchus and lung epithelium muscles stimulates adrenergic effects. this results in

lowering content of intracellular Ca2+ in bronchus muscles and bronchus relaxation. In parallel with this process, as the result of β2-activity stimulation, epithelial alveolar lung cells of type II produce larger amount of surfactant.

Administration of Prospan never impair central regulation of breath.

Sucklings and children aged up to 6 years are administered orally 2.5 mL 3 times a day; children aged over 6 years and teenagers are administered 5 mL 3 times a day, and adults are administered 5 to 7.5 mL 3 times a day.

Fizzy pills
For children aged 4 to 12 years: ½ of a fizzy pill 3 times a day (97.5 mg of dry ivy leave extract); for adults and children aged over 12: 1 fizzy pill 2 times a day. The medication shall be intaken on morning (day) and evening, previously having dissolved it in a glass of water (about 100 to 200 mL). Pills may be dissolved in both cold and hot water (for example, to prepare not drink enhancing bronchodilator properties of the medication).

For children aged 6 to 11 years, 1 stick (5 mL) 2 times a day which is equivalent to 70 mg of dry ivy leave extract; for adults and children aged over 12 years, solution of 1 stick (5 mL) 3 times a day which is equivalent to 105 mg of dry ivy leave extract. Prior to use, a stick shall be somewhat kneaded. The solution shall be intaken non-diluted on morning (midday) and evening.

Duration of treatment with Prospan shall be determined in every specific case depending on nature and severity of the disease, but it shall last at least 1 week. Besides, in order to reach stable therapeutic effect, the treatment, with the medication, shall be continued for other 2 or 3 days after having the disease symptoms removed.

Pregnancy and lactation periods: No reports on negative effect of the medication in periods of pregnancy or lactation. However, no special research for this category of patients was carried out.

Prospan cough syrup contains no alcohol, sugar, nor pigments. 30% (by volume) ethanol is used as sorbent for receiving the active ingredient from ivy leaves; in the following drying process, it is deleted from the extract completely.

For children aged up to 4 years, Prospan cough syrup is recommended. Prior to any use, the syrup vial shall be shaken. While being kept, the medication may become a little opaque, with syrup taste changed, but it will not impact therapeutic properties of the medication.


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