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Contractubex®

The notion that the scars adorn a man, is very doubtful. As for the scars in women – any comments are at all superfluous. Therefore, if scars could not be avoided – you need to fight with them. And Contractubex* gel can help with this.

The indications for use of Contractubex include hypertrophic and keloid scars (adhesions), stretch marks in pregnant women, contractures and scar strictures. Contractubex – is one of the few drugs of scars, registered not as a dietary supplement or a cosmetic product, but as a medicine. Its effectiveness is proven in numerous international studies. Already for a long time Contractubex – product No.1** from scars in the world.

Contractubex contains a combination of active ingredients: onion extract, heparin and allantoin. The drug reduces the growth of scar tissue, softens, smoothes, reduces inflammation, redness, itching, a feeling of tension in the scars, making them less noticeable.

Contractubex can be used in children (from 6 months – under the supervision of a physician), during pregnancy and lactation. Treatment should be started immediately after wound closure or removal of surgical sutures for best results.

Find more about drug Contractubex at: www.contractubex.com.ua

Contractubex gel: manufacturer Merz Pharma GmbH & Co KGaA, Germany, r. с. No. UA/6090/01/01

*Advertising: of a medicinal product. Read the instructions and consult a physician before use. Keep out of the reach of children.

Self-treatment may be harmful to Your health

Merz Pharma GmbH & Co. KGaA D03A Х

Active anti-scars gel.

Presentation:
10, 20 or 50 g gel tube, 1 tube in a carton box.

Composition:
100 g of gel contain:
Liquid onion extract 10 g/100 g
Heparin sodium 5000 IU/100 g
Allantoin 1 g/100 g

Other ingredients: methylparahydroxybenzoate, sorbic acid, xanthan gum, polyethylene glycol - 200, Fragrance 231616 aromatic oil, purified water.

Pharmacotherapeutic group: Medications used to treat wounds and ulceration. ATC code: D03A Х.

Indications:
Hypertrophic keloid scars that limit mobility and spoil the appearance after surgery, amputations, burns and other mechanical skin damage; fingers contracture (Dupuytren's contracture) and traumatic tendon contracture and scar stricture (atrophic scars).

Counterindications: Hypersensitivity to any medication ingredient.

Side effects:
Generally, Contractubex is well tolerated, even with long-term use. Some patients may experience the following side effects:

  • Skin: pruritus, erythema, telangiectasia, scar atrophy, hyperpigmentation, skin atrophy, hives, rash, skin irritation, papules, skin inflammation, burning sensation, skin tension feeling;
  • Common disorders and application site: edema, pain at the site of application;
  • Immune system: hypersensitivity (allergic reaction);
  • Infectious diseases: pustular eruptions.

Contractubex contains methyl 4-hydroxybenzoate and sorbic acid, which can cause topical allergic reactions.

Interactions: No any interaction experience has been reported.

Overdosage: No any overdosage experience has been reported.

Storage requirements: Keep out of the reach of children and at up to 25°С temperature.

Shelf life: 4 years.

Dispensing method: over the counter.

Pharmacodynamics. Contractubex exerts antiproliferative, anti-inflammatory, softening and smoothing effect on the scar tissue.

Onion extract exhibits anti-inflammatory effect due to inhibition of inflammatory mediators, and exerts anti-allergic effect. Besides, it inhibits proliferation and growth of fibroblasts of various origins, keloid fibroblasts, in particular. Also, they’ve proved inhibitory effect of onion extract in relation to mitosis (cell division), and decreased formation of extracellular matrix components from fibroblasts (e.g. proteoglycans). Onion extract also has a bactericidal effect. These properties stimulate primary wound healing and help to counteract unphysiological scarring.

Heparin has anti-inflammatory, anti-allergic, anti-proliferative effects, increases hydration of tissues and exerts softening effect on collagen structure. In the treatment of scars anti-inflammatory action of heparin and its effect on connective tissue matrix components are more important than the known antithrombotic effect.

Allantoin promotes wound healing and epithelialization, increases water binding of tissues. In addition, its keratolytic effect and the ability to improve permeability increase the effectiveness of other gel components. Allantoin also has a calming effect, reduces the severity of itching that often accompanies the process of scarring.

Synergistic effect of this combination is aimed at inhibiting proliferation of fibroblasts and abnormally accelerated collagen synthesis, in particular.

Pharmacokinetics. Not studied.

To adults and children from 2: apply required amount of gel several times a day, depending on the size of the scar, and gently rub down into the scar until complete absorption.

If you have solid, deep-rooted scars leave a gel under a bandage overnight. Depending on the size and thickness of the scar the treatment lasts from several weeks to several months.

Itching that sometimes occurs during Contractubex treatment, witnesses of tissue restructuring of scars. Usually, discontinuation is not required in this case. When treating fresh scars, avoid influence of cold, ultraviolet rays, vigorous massage.

Use in pregnancy and breastfeeding: there is no any data as to the risk of gel application during pregnancy and breastfeeding periods.

Effects on ability to drive vehicles or use other mechanisms: exerts no any effect.

Use in children: the medication is not indicated to children under 6 months. Before using medication in children aged 6 months - 2 years, it is advised to consult a doctor. The medication may be applied in children from 2.

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